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    Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts.

    The authors demonstrate that an activating mutation of β-catenin in mouse osteoblasts alters the differentiation potential of myeloid and lymphoid progenitors leading to development of acute myeloid leukaemia with common chromosomal aberrations and cell autonomous progression.  They also found increased β-catenin signalling and nuclear accumulation in the osteoblasts of 38% of patients with myelodysplastic syndromes or acute myeloid leukaemia. These patients also showed increased Notch signalling in haematopoietic cells.

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