In this paper the authors generated mice with osteocyte-specific expression of inducible Lrp5 mutations, which cause high and low bone mass phenotypes in humans. Bone properties of these mice were comparable to bone properties of mice with inherited mutations. They also induced an Lrp5 mutation in cells that form the appendicular skeleton but not in cells that form the axial skeleton and observed that bone properties were altered in the limb but not in the spine. These data argue that Lrp5 signaling functions locally and may be a target for therapeutic interventions.
Cui Y, Niziolek PJ, Macdonald BT, Zylstra CR, Alenina N, Robinson DR, et al