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    Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation.

    The authors tested the hypothesis that VEGF is an important regulator of mesenchymal precursor cell fate, determining whether differentiation gives rise to osteoblasts or adipocytes. Mice with conditional VEGF deficiency in osteoblastic precursor cells exhibited an osteoporosis-like phenotype characterized by reduced bone mass and increased bone marrow fat. In addition, reduced VEGF expression in mesenchymal stem cells resulted in reduced osteoblast and increased adipocyte differentiation.


    Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR.

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