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    Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

    The authors demonstrate that, in humans, the natural abundances of calcium (Ca) isotopes in urine change rapidly in response to changes in bone mineral balance (BMB). In a bed rest experiment, use of high-precision isotope ratio measurement allowed the onset of bone loss to be detected after about 1 wk, which was before bone mineral density had changed enough to be detectable with densitometry. This technology has potential to improve measurement of bone turnover and bone loss in human subjects.


    Morgan JL, Skulan JL, Gordon GW, Romaniello SJ, Smith SM, Anbar AD.

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