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    Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip.

    The regrowth of the distal tips of digits is models of tissue regeneration in mice. It had been assumed that limb regeneration derived from the blastema, an undifferentiated pluripotent cell population thought to be derived from mature cells via dedifferentiation. In this paper the authors show that a wide range of tissue stem/progenitor cells contribute towards the restoration of the mouse distal digit. Transplantation of cyan-fluorescent-protein-expressing haematopoietic stem cells, and parabiosis between genetically marked mice, confirmed that the stem/progenitor cells are tissue resident, including the cells involved in angiogenesis.


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