ASBMR/RBDA 2025 Symposium on Rare Bone Diseases: From the Genome to the Lived Experience

Thursday, September 4, 2025

The ASBMR/RBDA 2025 Symposium will be held on Thursday, September 4, 2025, one day prior the 2025 Annual Meeting, at the Seattle Convention Center in Seattle, Washington, USA. Organized by Leanne Ward, Ph.D. and Erik Imel, M.D., with guidance from Outi Makitie, Lynda Bonewald, Wolfgang Hogler, and Chelsey Grimbly, the goal of this topical meeting is to gather experts in rare bone diseases to promote interactions among basic, translational and clinical researchers and discuss the latest advances on skeletal dysplasias, disorders of ectopic mineralization, prevention of muscle and bone loss and the diagnosis and treatment of rare bone diseases.

Questions? Contact the ASBMR Business office by email at asbmr@asbmr.org or by phone at +1 (202) 367-1161.

Program

7:30 am - 8:00 am	Continental Breakfast

8:00 am - 9:45 am Session 1: Skeletal Dysplasias	8:00 am - 8:15 am Introduction & Overview - Leanne Ward & Erik Imel 8:15 am - 8:40 am Osteoclast-Osteoblast Feedback in Fibrous Dysplasia: Insights from Bench and Bedside - Luis de Castro 8:40 am - 9:05 am Novel Treatment Approaches in Fibrous Dysplasia - Alison Boyce 9:05 am - 9:30 am New, Disruptive Precision Therapies for Achondroplasia: Changing the Rules of the Game - Ravi Savarirayan 9:30 am - 9:45 am Talk from submitted abstracts
9:45 am - 10:00 am	Break
10:00 am - 12:00 pm Session 2: Disorders of Ectopic Mineralization	10:00 am - 10:25 am Overview of the Pathophysiology of ENPP1 Deficiency - David Weber 10:25 am - 10:50 am Hyperphosphatemic Familial Tumoral Calcinosis: Defining Mechanisms to Inform Treatment - Kelly Roszko 10:50 am - 11:15 am Emerging Therapies for Fibrodysplasia Ossificans Progressive - Edward Hsiao 11:15 am - 11:40 am XLH and Enthesopathy - Eva Liu 11:40 am - 11:55 am Talk from submitted abstracts
12:00 pm - 1:00 pm	Lunch & Poster Viewing
1:00 pm - 2:30 pm Session 3: Prevention of Muscle and Bone Loss	1:00 pm - 1:25 pm Mechanisms of Carpo-Tarsal Osteolysis from Pre-Clinical Models - Roland Baron 1:25 pm - 1:50 pm Clinical studies of vamorolone: An anti-inflammatory corticosteroid with unique structure/activity relationships: not metabolized by HSD11B's, and a MR antagonist - Erik Hoffman 1:50 pm - 2:15 pm Navigating Advocacy for Individuals with Duchenne Muscular Dystrophy in an Ever-Broadening Therapeutic Landscape - Pat Furlong 2:15 pm - 2:30 pm Talk from submitted abstracts
2:30 pm - 3:00 pm	Break
3:00 pm - 4:30 pm Session 4: From the Genome to the Lived Experience	3:00 pm - 3:25 pm Anti-Sclerostin Antibody for the Treatment of Osteogenesis Imperfecta - Ken Kozloff 3:25 pm - 3:50 pm Expanding Molecular Diagnoses in Rare Bone Disorders - Frank Rauch 3:50 pm - 4:15 pm Achondroplasia - Colleen Gioffreda 4:15 pm - 4:30 pm Talk from submitted abstracts
4:30 pm - 6:00 pm	Combined Pre-Meeting Reception & Poster Viewing